Top 10 Non-Invasive Glucose Monitors under Development
Diabetics are still awaiting a reliable, non-invasive means of blood glucose monitoring – one that doesn’t require breaking the skin or confirmation with a traditional monitoring method. The latest continuous glucose monitoring technology involves small sensors implanted in the skin that must be calibrated several times a day, and replaced every few days to a week to avoid infection. Because the blood sugar testers are implanted into the skin, the body sees the sensors as foreign objects, and frequently forms scar tissue around them.
Diabetics will soon be able to keep track of their blood sugar without enduring multiple daily finger pricks. A number of non-invasive blood glucose monitors are on the horizon.
Top 10 Non-Invasive Glucose Monitors
1) GlucoTrack Non-Invasive Glucose Monitors – Integrity Application’s GlucoTrack employs three different technologies: ultrasonic, conductivity and heat capacity. The device contains a main unit, a transmitter, a receiver and processor, and a sensor-containing ear clip. The main unit can support and store blood sugar readings for up to three users.
2) Symphony – Non-Invasive Glucose Monitors, Symphony is a biochemical sensor-based transdermal continuous glucose monitoring system with a wireless handheld device that reads the sensor’s measurements.
3) Multisensor Glucose Monitoring System – Developed by Solianis Monitoring Non-Invasive Glucose Monitors, this system delivers continuous information on glucose variations using impedance spectroscopy – a technology that uses frequencies to measure the effect of changes in blood glucose levels.
4) Portable blood glucose meter – Grove Instruments Non-Invasive Glucose Monitors are working on miniaturizing a prototype blood glucose monitor which delivers a reading using Optical Bridge technology. The user simply inserts his or her finger into a port to obtain an optically assessed blood sugar test reading in less than 25 seconds.
5) Glucose Monitor Tattoo Non-Invasive Glucose Monitors– Researchers at the Massachusetts Institute of Technology are testing a continuous glucose monitoring “tattoo” in which florescent nanoparticle ink is injected under the skin. The ink fluoresces in response to glucose when an infrared light is shone on it, telling a small monitor how much it detected.
6) Electronic thumb-pad sensor – Texas’ Baylor University researchers are testing an electronic thumb-pad sensor which detects blood glucose by measuring changes when electromagnetic energy waves pass through the skin.
7) I-SugarX – Freedom Meditech is pioneering the I-SugarX, an ophthalmic medical device which monitors changes in the eye to determine glucose levels. The user gazes into a handheld device which shines a light on the eye for less than a second, and then displays a digital blood glucose reading.
8) Near infrared optical spectroscopy – Inlight Solutions is developing devices that use near infrared optical spectroscopy and multi-variate analysis to measure blood glucose levels. The technology employs a light source, an optical detector, and a spectrometer.
9) LighTouch Technology – Uses a glucose test technology that projects a specific color of light onto a patient’s finger, and analyses the different colored light that is “re-projected” back from the finger to measure blood glucose levels.
10) C8Medisensors Non-Invasive Glucose Monitors design will transmit a painless pulse of light into the skin to detect glucose levels. Paired with Bluetooth technology, the glucose reading will be transmitted wirelessly to an easy-to-use display application on an ordinary Android smartphone.
If you haven’t heard of Grove Instruments, I recommend you check out their website and what they are doing. They claim to have developed a painfree/bloodfree way of testing your blood glucose level that leads the field in terms of accuracy, wiping traditional blood glucose meters out of the water. They state that:
The results of Grove’s clinical testing are unprecedented for a noninvasive device. The current international standard (ISO 15197) requires point of care glucose meters to vary from the blood standard by less than 20%. Grove’s MARD (mean average relative difference) has exceeded this standard (MARD 8-12%) for more than 2 years. The Company expects that soon a Grove device will be the world’s first-ever noninvasive glucometer to exceed all requirements of the ISO standard.
‘How does this cool device work?’ you might be asking. Good question. They say that:
Grove’s patented technology uses only very well perfused (high blood flow) sites – the fingertip or the earlobe. Grove’s technique also isolates the glucose signal to the blood compartment. Thus Grove’s glucometer uses neither an alternate site, nor an alternate fluid, rather, it gives a reading of real-time blood glucose, actionable for the management of diabetes. And it does it without pain, needles or a blood sample.
The test takes less than 20 seconds – considerably less than it takes to prepare the site, lance the skin, and process a blood sample as all currently available devices require. Real-time blood glucose in less than 20 seconds – obtained with a completely noninvasive (uses only light!) Grove Glucometer.
Reading further it seems all of the action comes from 3 laser diodes and an LED within the device. I’m really intrigued and can’t wait to see where this goes, and I know a lot of others in the DOC are also interested. Note that they are accepting applications of interest to participate in a clinical trial, which will be required before they can apply for FDA clearance.